diff --git a/src/oceanic_atom2.c b/src/oceanic_atom2.c
index 8d8bb62..6d07c0d 100644
--- a/src/oceanic_atom2.c
+++ b/src/oceanic_atom2.c
@@ -894,21 +894,37 @@ oceanic_atom2_device_open (dc_device_t **out, dc_context_t *context, dc_iostream
 		goto error_free;
 	}
 
-	// Give the interface 100 ms to settle and draw power up.
+	// Set the DTR line.
+	status = dc_iostream_set_dtr (device->iostream, 1);
+	if (status != DC_STATUS_SUCCESS) {
+		ERROR (context, "Failed to set the DTR line.");
+		goto error_free;
+	}
+
+	// Clear the RTS line to reset the PIC inside the data cable as it
+	// may not have have been previously cleared. This ensures that the
+	// PIC will always start in a known state once RTS is set. Starting
+	// in a known default state is very important as the PIC won't
+	// respond to init commands unless it is in a default state.
+	status = dc_iostream_set_rts (device->iostream, 0);
+	if (status != DC_STATUS_SUCCESS) {
+		ERROR (context, "Failed to clear the RTS line.");
+		goto error_free;
+	}
+
+	// Hold RTS clear for a bit to allow PIC to reset.
 	dc_iostream_sleep (device->iostream, 100);
 
-	// Set the DTR/RTS lines.
-	status = dc_iostream_set_dtr(device->iostream, 1);
+	// Set the RTS line.
+	status = dc_iostream_set_rts (device->iostream, 1);
 	if (status != DC_STATUS_SUCCESS) {
-		ERROR (context, "Failed to set the DTR line.");
-		return status;
-	}
-	status = dc_iostream_set_rts(device->iostream, 1);
-	if (status != DC_STATUS_SUCCESS) {
-		ERROR (context, "Failed to set the DTR line.");
-		return status;
+		ERROR (context, "Failed to set the RTS line.");
+		goto error_free;
 	}
 
+	// Give the interface 100 ms to settle and draw power up.
+	dc_iostream_sleep (device->iostream, 100);
+
 	// Make sure everything is in a sane state.
 	dc_iostream_purge (device->iostream, DC_DIRECTION_ALL);
 
diff --git a/src/oceanic_veo250.c b/src/oceanic_veo250.c
index de70c7b..a6038d8 100644
--- a/src/oceanic_veo250.c
+++ b/src/oceanic_veo250.c
@@ -272,6 +272,20 @@ oceanic_veo250_device_open (dc_device_t **out, dc_context_t *context, dc_iostrea
 		goto error_free;
 	}
 
+	// Clear the RTS line to reset the PIC inside the data cable as it
+	// may not have have been previously cleared. This ensures that the
+	// PIC will always start in a known state once RTS is set. Starting
+	// in a known default state is very important as the PIC won't
+	// respond to init commands unless it is in a default state.
+	status = dc_iostream_set_rts (device->iostream, 0);
+	if (status != DC_STATUS_SUCCESS) {
+		ERROR (context, "Failed to clear the RTS line.");
+		goto error_free;
+	}
+
+	// Hold RTS clear for a bit to allow PIC to reset.
+	dc_iostream_sleep (device->iostream, 100);
+
 	// Set the RTS line.
 	status = dc_iostream_set_rts (device->iostream, 1);
 	if (status != DC_STATUS_SUCCESS) {
diff --git a/src/oceanic_vtpro.c b/src/oceanic_vtpro.c
index d3387f2..cefeb7b 100644
--- a/src/oceanic_vtpro.c
+++ b/src/oceanic_vtpro.c
@@ -442,6 +442,20 @@ oceanic_vtpro_device_open (dc_device_t **out, dc_context_t *context, dc_iostream
 		goto error_free;
 	}
 
+	// Clear the RTS line to reset the PIC inside the data cable as it
+	// may not have have been previously cleared. This ensures that the
+	// PIC will always start in a known state once RTS is set. Starting
+	// in a known default state is very important as the PIC won't
+	// respond to init commands unless it is in a default state.
+	status = dc_iostream_set_rts (device->iostream, 0);
+	if (status != DC_STATUS_SUCCESS) {
+		ERROR (context, "Failed to clear the RTS line.");
+		goto error_free;
+	}
+
+	// Hold RTS clear for a bit to allow PIC to reset.
+	dc_iostream_sleep (device->iostream, 100);
+
 	// Set the RTS line.
 	status = dc_iostream_set_rts (device->iostream, 1);
 	if (status != DC_STATUS_SUCCESS) {